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Activated through the antibiotic rifampicin and several plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Reaction to certain ligands is species-certain. Activated by Obviously transpiring steroids, for instance pregnenolone and progesterone. Binds to a reaction aspect within the promoters on the CYP3A4 and ABCB1/MDR1